学龄高功能孤独障碍患儿脑白质结构的对照研究

The study on white matter structure changes in school aged children with high functioning autism

目的分析比较学龄高功能孤独障碍患儿大脑白质结构的异常。方法对17例高功能(IQ≥70)孤独障碍患儿(患者组)以及15名年龄、性别、智商与之相匹配的正常儿童(对照组)进行T1加权三维MRI成像,应用基于像素的形态测量法(VBM)等分析比较两组脑白质体积的差异。结果与正常对照组相比,患者组大脑左侧半球白质的总体积减少(P=0.050),右前扣带回以及左顶上小叶区域脑白质体积显著减少(P<0.001)。结论学龄高功能孤独障碍患儿脑白质体积异常明显,脑白质的异常可能是学龄孤独障碍的重要病理机制之一。

Objective To assess the volume difference in the cerebral white matter between school aged children with high functioning （ IQ≥70） autism （HFA） and healthy children controls. Methods Voxel based morphometry （VBM） in conjunction with statistical parametric mapping was applied to the structural magnetic resonance images of 17 HFA patients and 15 normal controls. Results Compared with the controls, the white matter volume in HFA patients sig- nificantly decreased in the left hemisphere （ P = O. 050）, right anterior cingulated and left superior parietal lobule （ P 〈 O. 001 ）. Conclusions Our study reveals decreases in volume of white matter in HFA which suggest that deficits in white matter is one of the important pathological changes in school aged HFA.