2-羟基-3,6-二氯苯甲酸的合成工艺研究

Synthesis of 2-hydroxy-3, 6-dichlorobenzoates

以2,5-二氯苯酚为原料,经成盐脱水、羧化、酸析合成了2-羟基-3,6-二氯苯甲酸,应用新型羧化催化剂,使羧化收率从原来的65%上升到87%,总收率达86%以上。

2-hydroxy-3, 6-dichlorobenzoates was prepared from 2, 5-dichlorophenol through forming salt and dehydration, carboxylation, the acidification. The new catalyst BKC-3 was applied to carboxylation reaction, and the carboxylation yield was raised from 65% to 87%.