尼莫地平治疗高血压脑出血58例临床疗效观察

Clinical Observation of the Curative Effects of Nimodipine on Cerebral Hemorrhage in the Patients with Hypertension

目的:观察尼莫地平对高血压脑出血患者的脑血肿、脑水肿体积的影响和临床疗效。方法:58例高血压脑出血患者被随机分成尼莫地平治疗组和对照组,在治疗前、治疗后第7天及第14天测量脑血肿和脑水肿带的体积,同时在入院时、发病后14天和60天随访进行ESS评分,比较其治疗效果。结果:尼莫地平治疗组患者较对照组患者脑血肿、脑水肿体积明显减小,ESS评分明显高于对照组。结论:在高血压脑出血的早期可以使用尼莫地平,达到减轻脑水肿、促进脑血肿的吸收和改善高血压脑出血患者的神经功能的作用。

Objective： To observe the curative effects of the nimodipine on the volume of hematoma and perilesional edema and neurological function in the patients with cerebral hemorrhage. Methods： 58 patients with cerebral hemorrhage were randomly divided into 2 groups, nimodipine therapeutic group and the control group. The volume of hematoma and perilcsional edema was measured by CT scan 7 and 14 days before the treatment, and on the 7th day, 14th day after the treatment. ESS was measured before treatment when admitted to the hospital and on the 14th day and the 60th day after hemorrhage. Results： The volume of hematoma and perilesional edema of the patients in the nimodipine therapeutic group decreased significantly compared with that of the control group, the ESS was also significantly higher than that in the control group. Conclusion： Nimodipine can reduce the volume of hematoma and perilesional edema and improve neurological function in the early stage of cerebral hemorrhage.