摘要
辣椒素(capsaicin,CAP)药理作用广泛,其对内脏痛觉过敏(visceral hyperalgesia,VHL)的影响已引起广大学者的关注.研究显示小剂量CAP可能诱发VHL,而大剂量的CAP可能对VHL有抑制作用.CAP对VHL的作用机制可能与CAP受体(vanilloid receptor subtype1,VR1)及其VR1的磷酸化和去磷酸化、P物质(SP)、降钙素基因相关肽(CGRP)、蛋白水解酶激活型受体2(protease-activated receptor2,PAR2)等有关.CAP可能成为一种有前景的治疗VHL的新药.
Capsaicin (CAP) has multiple pharmacological actions, and researches have been centered on its effect on visceral hyperalgesia (VHL). Relevant studies have shown that low doses of CAP may cause VHL, while high doses can inhibit VHL. This kind of mechanism may be associated with vanilloid receptor subtype I (VR1) phosphorylation and dephosphorylation, substance P (SP), calcitonin-gene-related peptide (CGRP) and protease-activated receptor 2 (PAR2). CAP may be promising as a new drug for VHL treatment.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第34期3884-3889,共6页
World Chinese Journal of Digestology
关键词
辣椒素
内脏痛觉过敏
机制
Capsaicin
Visceral hyperalgesia
Mechanism