核苷类药物抗病毒治疗对HBV感染者血清IFN-γ和IL-2水平的影响及临床意义

Effects of Nucleic Acids Antiviral Therapy on Serum IFN-γ and IL-2 in Patients with Chronic Hepatitis B

目的:探讨乙型肝炎病毒(HBV)慢性感染者抗病毒治疗后外周血Th1型细胞因子的水平变化及其临床意义。方法:分别在核苷类药物(拉米夫定与阿德福韦)抗病毒治疗前后,分离39例HBV感染者临床血清标本,用双抗体ELISA夹心法分别定量检测血清的IFN-γ和IL-2水平。结果:慢性乙型肝炎患者抗病毒治疗后血清IFN-γ水平较治疗前明显升高(P<0.05);而IL-2则无明显变化(P>0.05)。慢性乙型肝炎患者抗病毒治疗后完全应答组的IFN-γ和IL-2的水平均明显高于不完全应答组(P<0.05)。结论:抗病毒治疗可促进慢性乙肝患者的Th1型细胞因子分泌,有利于HBV的清除。

Objective： To investigate the clinic significance of serum IL - 2 and IFN -γ level changes in Hepatitis B virus infection patients who received nucleic acids antiviral therapy. Methods： Before and after the treatment, the IL - 2 and IFN -γ in serum levels of 39 patients infected with hepatitis B were detected by ELISA, respectively. Results ： IFN - γ levels of patients after the treatment was obviously higher than before the treatment （ P 〈 0.05） ,and there was no significant difference about IL - 2（ P 〉 0.05） .IL - 2 and IFN -γ levels of the patients who had a good curative effect were both obviously higher than those who did not have a good curative effect （ P 〈 0.05）. Conclusion： the results suggest that nucleic acids antiviral therapy could improve the cell immune reaction against HBV and benefit for HBV elimination in patients with CHB.