牛磺酸预处理对大鼠离体心脏缺血再灌损伤血流动力学的影响

Effects of Taurine on Hemodynamics in Isolated Rats Hearts Against Ischemia and Reperfusion Injury

目的:观察牛磺酸对大鼠离体心脏缺血再灌损伤血流动力学的影响。方法:40只大鼠随机分为4组:缺血再灌组(I/R),预适应组(IPC),牛磺酸Ⅰ组,牛磺酸Ⅱ组。采用Langendorff离体心脏灌流方法,经主动脉用K-H液平衡灌注。记录左室舒张末压(LVEDP)、左室收缩压(LVSP)、左室压力上升和下降最大变化速率(±dp/dtmax)、冠脉流量(CF)。结果:与I/R组比较,牛磺酸预处理能提高大鼠离体心脏停灌再灌期的CF,升高LVSP、±dp/dtmax而降低LVEDP,其差异有显著性(P<0.05)。结论:牛磺酸预处理对大鼠离体心脏停灌再灌注损伤具有保护作用。

Objective：To investigate the effect of taurine preconditioning on myocardium against ischemia - reperfusion （I/R） injury. Methods ： Fourty SD rats were randomly divided into 4 groups ： ischemia - reperfusion（I/ R） group, isehemic preconditioning（IPC） group, taurine I group, taurine 11 group. Krebs - Henseleit buffer was perfused into the hearts in langendorff model. During reperfusion, left ventricular end - diastolic pressure （LVEDP） and left ventricular systolic pressure （LVSP）, ＋ dp/dt max, the coronary effluent （CF） were determined. Results ： LVSP, ＋ dp/dt max, CF had a significant improvement in taurine groups, however LVEDP was decreased in taurine groups. Conclusion ：Taurine preconditioning had protective effects on myocardium against I/R injury.