α-呋喃丙烯酸丙酯的合成研究

Synthesis of α-Propyl Furancrylates

报道了糠醛经Knoevenagel反应和酯化反应制备α-呋喃丙烯酸丙酯的新方法.以SO42-/ZrO2作为催化剂,在无溶剂条件下,糠醛与丙二酸发生Knoevenagel缩合制备了α-呋喃丙烯酸,采用正交试验优化了缩合反应条件,产率94%;采用TiSiW12O40/TiO2作催化剂,α-呋喃丙烯酸与正丙醇酯化合成了α-呋喃丙烯酸丙酯,无需带水剂,产率92.4%,α-呋喃丙烯酸丙酯的含量达99.1%;探讨了醇酸物质的量比值、反应时间和催化剂用量等对酯化反应产率的影响.

A novel method for synthesizing α-propyl furancrylates by Knoevenagel condensation and esterification of furaldehyde was reported. The Knoevenagel condensation of furaldehyde with malonate was carried out by SO4/^2- ZrO2 catalyst under solvent-free conditions in 94% yield. The optimize condensation conditions were investigated via orthogonal experiment, α-Propyl furancrylates was synthesized by TiSiW12 O40/TiO2 catalyst from α-furancrylic acid and propanol with 92.4% yield and 99.41% purity. The effects of mole ratio of α-furancryhc acid and alcohols, reaction time, and quantity of catalyst on esterification were discussed.