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CD147和MMP-2在卵巢上皮癌中的表达及意义 被引量：1

Expression and Significance of CD147 and MMP-2 in Epithelial Ovarian Cancer
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摘要 目的探讨细胞外基质金属蛋白酶诱导因子(CD147)和基质金属蛋白酶-2(MMP-2)在卵巢上皮癌中的表达特点及生物学行为关系。方法应用免疫组化S-P法检测45例卵巢上皮癌、10例交界性卵巢上皮肿瘤、15例良性卵巢上皮肿瘤及15例正常卵巢组织中的CD147和MMP-2的表达情况。结果CD147和MMP-2在卵巢上皮癌中的阳性表达率分别为77.8%和84.4%,均高于其他分组的卵巢组织(P<0.05),二者的阳性表达与组织分化和临床分期有关,而与组织类型无关。CD147和MMP-2表达具有相关性(P<0.05)。结论CD147和MMP-2的表达与卵巢上皮癌发生、发展、增殖和浸润密切相关。 Objective To investigate the relationship and the biology behaviors between the expressions of CD147 and MMP-2 in epithelial ovarian cancer. Methods The expression of CD147 and MMP-2 were examined by immunohistochemical S-P staining method in 45 cases with ovarian cancer, 10 eases with borderline epithelial ovarian tumors, 15 cases with benign epithelial ovarian tumors and 15 cases with normal ovarian tissue. Results The positive rates of CD147 and MMP-2 in epithelial ovarian cancer were 77.8% and 84.4% , which were higer than those in other groups of ovarian tissue （ P 〈 0.05）. The expression of CD147 and MMP-2 were closely correlated with pathological grades and clinical stage （ P 〈 0. 05 ）, but no association was observed with histological type. MMP-2 had positive correlation with CD147. Conclusion The expression of CD147 and MMP-2 is closely related with development proliferation and invasion in epithelial ovarian cancer.
作者 焦娜 薛秀珍
机构地区 河南科技大学第一附属医院
出处 《河南科技大学学报（医学版）》 2008年第4期248-250,共3页 Journal of Henan University of Science & Technology:Medical Science
关键词 卵巢上皮癌 细胞外基质金属蛋白酶诱导因子 基质金属蛋白酶-2 免疫组织化学 epithelial ovarian cancer extracellular matrix metalloproteinase inducer matrix mctalloproteinase-2 immunohistochemistry
分类号 R737.31 [医药卫生—肿瘤]
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参考文献10

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河南科技大学学报（医学版）
2008年 第4期

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