基于知识表达系统的序列比对研究

Sequence Alignment Research Based on Knowledge Representation System

序列比对是生物信息学中基本的信息处理方法,对于发现生物序列中的功能、结构和进化信息具有重要的意义。该文对典型的双序列比对算法以及多序列比对算法进行了描述和评价;针对目前序列比对算法普遍存在的不足,提出了一种新的思想--基于知识表达系统的序列比对研究,应用知识表达系统对序列比对相似性发现进行定义及其处理。

Sequence alignment is a basic information processing method in bioinformatics and useful for discovering functional, structural, and evolutionary information in biological sequences.Typical pair-wise sequence alignment algorithms and multiple sequence alignment algorithms are described and evaluated in this paper. After analyzing difficulties in sequence alignment, a new idea-sequence alignment research base on knowledge representation system is discussed. This paper describes the definition and data processing of knowledge representation system in this sequence alignment research.