羊栖菜多糖对高血脂模型大鼠血脂和抗氧化功能的影响

Effects of polysaccharide from Sargassum fusiforme on blood-lipids and antioxidation ability in hyperlipemia rats

目的观察羊栖菜多糖对高血脂大鼠的降血脂和抗氧化作用。方法建立高血脂大鼠模型,羊栖菜多糖(SFPS)0.4、0.8、1.6g.kg-1.d-1灌肠给药4周,比色法检测羊栖菜多糖对模型大鼠总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和脂质过氧化物(LPO)、丙二醛(MDA)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶GSH-Px)的影响。结果和结论羊栖菜多糖能显著降低高血脂模型大鼠血中TC、TG和LDL-C的含量,降低LPO浓度和MDA含量,同时升高HDL-C的含量,增强SOD和GSH-Px的活性。

Objective To investigate the effects of polysaccharide from Sargassurn fusiforrne on blood-lipid and antioxidation ability in hyperlipemia rats. Methods The hyperlipemia rats as the experimental animal were established by feeding with fat-rich forage, meanwhile the rats were ig SFPS at doses of 0. 4,0. 8,1. 6g·kg^-1 for 4wk. The levels of blood-lipid and the indices of antioxidation ability which include the total cholesterol（TC）, triglyceride（TG）, lowdensity lipoprotein cholesterol（LDL-C）, high-density lipoprotein cholesterol（HDL-C）, lipid peroxidation（LPO）, malonaldehyde （MDA）, superoxide dismutase （SOD） and glutathion peroxidase（GSH-Px） were determined. Results and Conclusion SFPS could significantly reduce the contents of TC,TG,LDL-C,LPO and MDA. In the mean time, SFPS increased the content of HDL-C and enhanced the activities of SOD and GSH-Px.