1Takashi M,Yasuhiro F K, Naoshige A. Characterization of fucoxanthin and fucoxanthinol esters in the Chinese surf clam, Mactra chinensis[J]. J Agric Food Chem, 2007,55: 1563.
4Takahiko H, Larry L,Swift, etal. Discovery of 5R- lipoxygenase activity in oocytes of the surf clam,Spisula solidissima[J]. Bioch imic'a et Bioph ysica Acta , 1997,1346:109.
5Rinehart, Kenneth, Lloyd. Spisulosine compounds having antitumour activity [ P ]. PCT Int. Appl. WO9952521A1. 1999-10-21.
6Cuadros R, Montejo de Gareini E, Wandosell F, et al. The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers[J]. Cancer Lett, 2000,152 : 23.
7Newman DJ,Cragg GM. Marine natural products and related compounds in clinical and advanced preclinical trials [J]. J Nat Prod,2004,67:1216.
8Sancheza Ana M,Sophie Malagarie-Cazenavea,Nuria Olea, et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCγ activation[J]. European Journal of Pharmacology, 2008,584:237.
9Thomas, Lyell J. A blood anticoagulant from surf clams[J]. Biol Bull ,1951,101:230.
10Burson, Fahrenbach. Isolation and purification of mactins,heparin-like anticoagulants from mollusca[J]. Biol Bull, 1956,78: 5874.