精制血府胶囊对犬急性心肌缺血心脏血流动力学和心肌耗氧量的影响

Effect of Purified Xuefu Capsule on Cardiac Haemodynamics and Oxygen Consumption in Acute Myocardial Ischemia of Experimental Dogs

目的：探讨精制血府胶囊对犬急性心肌缺血心脏血流动力学和心肌耗氧量的作用机理。方法：采用结扎犬冠状动脉的方法造成急性心肌缺血模型，十二指肠给药，观察其对缺血心脏冠状动脉血流量、心输出量及心脏收缩舒张功能等的影响。结果：结扎犬冠状动脉造成急性心肌缺血后，空白对照组心脏收缩舒张功能减退、冠状动脉血流量及心输出量降低，而精制血府胶囊组各项指标均有一定改善，大剂量组更为显著，并可降低心肌耗氧量。结论：精制血府胶囊可保护火急性心肌缺血心脏的泵血功能，其机理可能与降低心肌耗氧量、增加心肌供血有关。

Objective: To investigate the effect of Purified Xuefu Capsule (PXC) on cardiac haemodynamic and oxygen consumption in acute myocardial ischemia of experimental dogs. Methods: The coronary arteries was ligated to create the myocardial ischemic modle and gave them PXC through the duodenum. The effect of PXC on the systolic and diastolic function, volume of blood flow in coronary arteries and cardiac output of acute ischemic heart of experimental dogs were examined. Results: After ligation of the coronary artery the myocardial ischemia was formed, the systolic and diastolic function, volume of blood flow in coronary arteries and cardiac output were decreased significantly in the control group, whereas these indexes in high-dose and low-dose.PXC group were improved to some extent, the effect of high-dose PXC group was better than that of the low-dose PXC group. Furthermore high dose PXC could reduce the oxygen consumption. Conclusions: PXC could prevent the cardiac pump function from acute myocardial ischemia of experimental dogs. The mechanism may be related to reduce the oxygen consumption and increase the blood supplement to myocardium.