期刊文献+

卵巢上皮性癌ER、PR和Ki67表达及其临床意义分析

Expressions of ER,PR and Ki67 in Epithelial Ovarian Cancer and Their Clinical Significance
原文传递
导出
摘要 [目的]研究ER、PR和Ki67在卵巢上皮性癌中的表达及其临床意义。[方法]用单克隆抗体、免疫组化技术测定74例原发性卵巢上皮性癌患者中ER、PR和Ki67的表达。[结果]ER、PR、Ki67的阳性表达率分别是59.5%、60.8%、74.3%,PR表达与临床分期相关。多因素分析显示PR表达、临床分期是独立的预后因素。[结论]在卵巢上皮性癌中,PR表达、临床分期具有独立的判断患者预后的价值。
机构地区 解放军第
出处 《肿瘤学杂志》 CAS 2008年第12期966-968,共3页 Journal of Chinese Oncology
  • 相关文献

参考文献15

  • 1Novichkov EV, Votintsev AA. Ovarian cancer prognosis and expression of receptors to sex hormones and proliferative activity of tumor cells [J].Arkh Patol,2006,68(2):10-13.
  • 2Hφgdall EV, Christensen L, Hφgdall CK, et al. Prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: from the ‘MALOVA' ovarian cancer study[J]. Oneol Rep, 2007, 18 (5):1051-1059.
  • 3Langdon SP, Gabra H, Bartlett JM, et al. Functionality of the progesterone receptor in ovarian cancer and its regulation by estrogen[J].Clin Cancer Res,1998,4(9):2245-2251.
  • 4Munstedt K, Steen J, Knauf AG, et al.Steroid hormone receptors and long term survival in invasive ovarian cancer [J]. Cancer, 2000,89(8):1783-1791.
  • 5Spurdle AB, Webb PM, Purdie DM, et al. No significant association between progesterone receptor exon 4 Va1660Leu G/T polymorphism and risk of ovarian cancer [J]. Carcinogenesis, 2001, 22(5):717-721.
  • 6De Sousa Damiao R, Fujiyama Oshima CT, Stavale JN, et al. Analysis of the expression of estrogen receptor, progesterone receptor and chicken ovalbumin upstream promoter-transcription factor Ⅰ in ovarian epithelial cancers and normal ovaries[J]. Oncol Rep, 2007, 18(1):25-32.
  • 7Bu SZ,Yin DL, Ren XH, et al. Progesterone induces apoptosis and up regulation of p53 expression in human ovarian carcinoma cell [J]. Cancer, 1997, 79(10):1944-1950.
  • 8Lindgren PR,Cajander S, Backstrum T, et al. Estrogen and progesterone receptors in ovarian epithelial tumors[J]. Mol Cell Endocrinol, 2004, 221(1-2):97-104.
  • 9Syed V,Mukherjee K,Godoy-Tundidor S,et al. Progesterone induces apoptosis in TRAIL-resistant ovarian cancer cells by circumventing c-FLIPL overexpression [J]. J Cell Biochem, 2007, 102(2):442-452.
  • 10罗军,周炜,彭芝兰,王和,范余娟,钱晓蕾,程易凡,杨开选.应用组织芯片技术分析卵巢癌组织中Ki67的表达[J].实用癌症杂志,2003,18(3):263-265. 被引量:2

二级参考文献29

  • 1[1]Gerdes J,Schwab U,Lemke H,et al.Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer,1983,31:13-20.
  • 2[2]Oltvai ZN,Milliman CL,Korsmeyer SJ.bcl-2 heterodimerizes in vivo with a conservd homologe ,bax,that accelerates programed cell death.Cell,1993,74:609-619.
  • 3[3]Krajewski S,Blomqvist C,Franssila K,et al.Reduced expression of proapoptotic gene bax is associated with poor response rates to combination chemotherapy and shorter survival in woman with metastatic breast adenocarcinoma.Cancer Res,1995,55:4471-4478.
  • 4[4]Xie X,Clausen OPF,Angelis PD,et al.The prognostic value of spontaneous apoptosis,bax,bcl-2,and p53 in oral squamous cell carcinoma of the tongue.Cancer ,1999,86:913-920.
  • 5[5]Brambilla E,Negoescu A,Gazzeri S,et al.Apoptosis related factors p53,bcl-2 and bax in neuroendocrine lung tumors. Am J Pathol,1996,149:1941-1952.
  • 6[6]Anttila M,Kosma VM,Ji H,et al.Clinical significance of d-catenin,collagen Ⅳ,and ki67 expression in epithelial ovarian cancer.J Clin Oncol,1998,16:2591-2600.
  • 7[7]Jürgensmeier JM,Xie Z,Deveraux Q,et al.bax directly induces release of cytochrome C from isolated mitochondria.Proc Natl Acad Sci USA,1998,95:4997-5002.
  • 8[8]Stroble T,Swanson L,Korsmeyer S,et al.bax enhances paclitaxel-induced apoptosis through a p53-independent pathway.Proc Natl Acad Sci USA,1996,93:14094-14099.
  • 9[9]Tai YT,Lee S,Niloff E,et al.bax protein expression and clininal outcome in epithelial ovarian cancer.J Clin Oncol,1998,16:2583-2590.
  • 10[10]Campos L,Rouault JP,Sabido O,et al.High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy.Blood,1993,81:3091-3096.

共引文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部