幽门螺杆菌感染对胃癌患者血清中IL-8和NO含量的影响

The Influence of Helicobacter Pylori Infection on the Content of IL-8 and NO in Serum of Gastric Cancer Patients

目的:检测胃癌患者血清中白细胞介素-8(IL-8)和一氧化氮(NO)的浓度,探讨幽门螺杆菌(HP)感染对胃癌患者血清中IL-8和NO含量的影响。方法:胃癌患者60例,根据HP检测结果分为HP阳性组和HP阴性组,以ELISA法检测血清IL-8浓度,硝酸盐还原酶法检测血清NO浓度,比较两组IL-8、NO浓度的差异。结果:HP阳性胃癌患者血清中的IL-8含量(365.69±51.78)较阴性患者(257.58±57.35)增加,两组差异有显著性意义,P<0.05);HP阳性胃癌患者血清中的NO含量(35.02±7.13)较阴性患者(39.78±5.07)降低,两组差异有显著性意义,P<0.05。结论:胃癌患者血清IL-8和NO浓度的变化与HP感染密切相关。

Objectives： 60 cases of gastric cancer patients were divided into two groups according to the results of HP determination. The content of IL - 8 and NO in serum were determined by ELISA and nitrate reductase assay respectively. Methods： The ultrasonic imaging characteristics of 2, 274 cases of patients treated with ultmsonography before and after LC were retrospectively analyzed. Resuits： The content of IL- 8 in HP- positive group patients was higher than that of HP- negative group, and there had significant statistical difference between these two groups （ P 〈 0. 05）. The content of NO in HP - positive group patients was lower than that of HP - negative group, and there had significant statistical difference between these two groups （P 〈 0. 05）. Conclusions： The content variation of IL- 8 and NO in serum is closely related with HP infection for gastric cancer patients.