培哚普利与卡托普利治疗原发性高血压各60例的比较

Perindopril vs captopril in treating essential hypertension each 60 patients

目的 :比较培哚普利与卡托普利对原发性高血压的治疗作用。方法 :中度原发性高血压病人12 0例 ,随机分为 2组。培哚普利组 60例 (男性 4 5例 ,女性 15例 ;年龄 60±s 15a) ,采用培哚普利 4～ 8mg ,po ,qd× 4wk ;卡托普利组 60例 (男性 4 5例 ,女性 15例 ;年龄 60± 14a) ,采用卡托普利 12 .5～ 2 5mg ,po ,tid× 4wk。每组 16例进行了 2 4h动态血压监测。结果 :培哚普利组总有效率为92 % ,卡托普利组总有效率为 78% ,2组差异不显著(P >0 .0 5) ;不良反应发生率 ,培哚普利组 12 % ,卡托普利组 2 8% (P <0 .0 5) ,均轻微。结论 :培哚普利与卡托普利对中度高血压病疗效均较好 。

AIM: To compare the effects of perindopril and captopril in treating essential hypertension. METHODS: patients with moderate essential hypertension (n=120) were randomly assigned to 2 groups. Perindopril group of 60 patients (M 45, F 15; age 60±s 15 a) received peridopril 4_8 mg, po, qd, for 4 wk. Captopril group of 60 patients (M 45, F 15; age 60±14 a) received captopril 12.5_25 mg, po, tid, for 4 wk. The efficacy of 32 (each group 16) hypertension patients were evaluated by 24 h ambulatory blood pressure monitoring. RESULTS: the total efficacy was 92% in the perindopril group and 78% in the captopril group (P>0.05). The rate of adverse reaction was 12% in the perindopril group and 28% in the captopril group (P<0.05), but all were mild. CONCLUSION: Perindopril and captopril has similar hypotensive effect, but perindopril is a much safer drug.