环丙沙星治疗复治涂阳肺结核

Ciprofloxacin in treating smear_positive retreated pulmonary tuberculosis

目的 :观察环丙沙星治疗复治涂阳肺结核的疗效。方法 :将 146例复治涂阳肺结核病人分为治疗组 77例 (男性 51例 ,女性 2 6例 ,年龄 4 6±s 11a) ,对照组 69例 (男性 4 5例 ,女性 2 4例 ,年龄 4 9±11a) ,2组均应用HRZE方案 :异烟肼 (H) 0 .3g/d ;利福平 (R) 0 .4 5g/d(体重 >60kg者 0 .6g/d) ;吡嗪酰胺 (Z) 1.5g/d ;乙胺丁醇 (E) 0 .75g/d ,吡嗪酰胺为bid ,其余 3药均晨间空腹顿服 ,治疗组加环丙沙星 ,体重≥ 55kg者 0 .3g ,体重 <55kg者 0 .2 g ,po ,bid ,连用 6mo。结果 :治疗组和对照组治疗mo 6痰菌阴转率分别为 93%和 64% (P <0 .0 1) ,有显著性差异。结论

AIM: To observe the efficacy of ciprofloxacin in treating smear_positive pulmonary tuberculosis. METHODS: One hundred and forty_six patients with smear_positive retreated pulmonary tuberculosis were divided into two groups: 77 patients (M 51, F 26, age 46±s 11 a) in treatment group, 69 patients as control group (M 45, F 24, age 49± 11 a). All patients received HRZE: isoniazid (H) 0.3 g, rifampicin (R) 0.45 g or 0.6 g(BW>60 kg), and ethambutol (E) 0.75 g once daily before breakfast, and pyrazinamide (Z) 0.75 g (twice a day). The treatment group received, in addition, ciprofloxacin 0.3 g (BW≥55 kg) or 0.2 g (BW<55 kg) twice daily. The treatment lasted 6 mo. RESULTS: At the end of 6 mo, sputum_negative rate in the treatment group (93%) was higher than that in the control group (64%), P<0.01. CONCLUSION: Ciprofloxacin is recommended in treating smear_positive retreated pulmonary tuberculosis.