西沙必利对胆囊切除术后的胃肠蠕动作用

Therapeutic effect of cisapride on gastrointestinal peristalsis after cholecystectomy

目的 :观察西沙必利对胆囊切除术后胃肠功能恢复的疗效。方法 :采用双盲随机将 12 0例胆囊切除术后的病人分为 2组。西沙必利组 60例 (男性18例 ,女性 4 2例 ,年龄 4 5±s 8a) ,术前 2h用西沙必利 10mg ,po ,术后用 10mg ,po ,q 6h ,直至肛门排气。安慰剂组 60例 (男性 2 2例 ,女性 38例 ,年龄 4 3± 6a) ,服安慰剂 (维生素C) 2片 ,服法与西沙必利组相同。通过询问肛门排气时间来观察疗效。结果 :西沙必利使胆囊切除术后肛门排气时间 (术后13h)较安慰剂组 (术后 39h)明显缩短 (P <0 .0 1)。结论

AIM: To observe the therapeutic effect of cisapride on restoration of gastrointestinal function in patients after cholecystectomy. METHODS: One hundred and twenty patients after cholecystectomy were randomly assigned to 2 gorups with a double-blind method: 60 patients (M 18, F 42, age 45±s 8 a) were treated with cisapride 10 mg, po, 2 h preoperatively and 10 mg, po, q 6 h postoperatively until wind break. Another 60 patients (M 22, F 38, age 43±6 a) received placebo (vitamin C) 2 tablets. 2 h preoperatively and 2 tablets, q 6 h postoperatively served as control. RESULTS: The duration of the recovery time (13 h after operation) of the gastrointestinal function in cisapride group was shorter than that (39 h after operation) in control group (P<0.01). CONCLUSION: Cisapride accelerates the restoration of gastrointestinal function in patients after cholecystectomy.