丙戊酸钠缓释片治疗儿童癫痫的疗效及血药浓度

Efficacy and serum drug concentration of sustained release sodium valproate in treatment of childhood epilepsy

目的 :评价丙戊酸钠缓释片治疗儿童癫痫的疗效及稳态期血药浓度。方法 :30例患各种类型癫痫的儿童 (男性 2 2例 ,女性 8例 ;年龄 8.2±s 2 .4a)服丙戊酸钠缓释片 ,剂量为 2 3.8± 2 .9mg/(kg·d) ,qn。治疗d 10 ,服药后 12h和 2 4h(下次服药前 )采血标本 ,用TDx方法测定血清丙戊酸浓度。疗效随访期为 11± 3mo。结果 :稳态期 ,服药后 12h和 2 4h血丙戊酸浓度分别为 10 5± 16mg/L及 68± 13mg/L ,波动指数 (FI)为 0 .4 1。发作控制率为77% ,显效率为 2 0 % ,无明显不良反应。结论 :丙戊酸钠缓释片每日服用

AIM: To evaluate the efficacy and serum drug levels in steady state of sustained-release sodium valproate (VPA-Na·SR) in treatment of childhood epilepsies. METHODS: Thirty children (M 22, F 8; 8.2±s 2.4 a) with a variety of epilepsies were treated with VPA-Na·SR 23.8±2.9 mg/(kg·d), po, qn. The serum valproic acid (VPA) concentration was determined by TDx. Blood samples were taken at 12 h and 24 h(prior to the next dosing) after the evening dose on d 10 of therapy. The following-up period was 11±3 mo. RESULTS: In steady state, the serum VPA level of 12 h and 24 h after drug-dosing was 105±16 mg/L and 68±13 mg/L, respectively. The FI was 0.41. The controlled rate of seizures was 77%, excellent response rate was 20%. No significant adverse effect was seen. CONCLUSION: VPA-Na·SR is an effective drug for the treatment childhood epilepsy.