可乐定贴片戒烟效果

Effects of clonidine patch on smoking cessation

目的 :观察可乐定贴片戒烟效果。方法 :自愿戒烟者 2 0人 ,随机、双盲分为 2组 ,每组各 10人。用药组于胸部贴可乐定贴片 2片 ( 2 .5mg/片 ) ,1wk更换 1次 ,连续 5wk ;安慰剂组 ,用空白贴片 ,其他完全相同。依据尿尼古丁代谢物 (可替宁 )及症状综合评价。结果 :2组吸烟量均显著减少 ,但可乐定贴片减轻焦虑、激惹等症状较明显。所用的可乐定剂量可使血压和心率稍有下降 ,但不影响继续用药。结论

AIM: To observe the effects of transdermal clonidine treatment on withdrawal syndrome associated with smoking cessation. METHODS: Twenty smokers were randomized into 2 groups: (1) receiving 2 clonidine patches (2.5 mg/patch) which deliver approximately 0.2 mg of clonidine per day; (2) placebo patches. The patches were identical in appearance and the procedure was double_blind. Patch use was continued for 5 wk. The urinary cotinine (nicotine metabolite) was tested to evaluate the effects in refraining from cigarette smoking. RESULTS: The number of cigarettes smoked per day both in clonidine and placebo groups was decreased. Obvious alleviation of some withdrawal symptoms (e.g. anxiety and irritability) in clonidine group was noted. Side effects were generally mild, reduction of blood pressure and of heart rate were seen in clonidine group. CONCLUSION: Transdermal clonidine treatment ameliorates some of the short_term withdrawal symptoms.