依达拉奉联合杏丁治疗大面积脑梗死临床疗效观察

Therapeutic Effect of Edaravone and Xingding on Treating Acute Cerebral Infarction of Large Area

目的观察依达拉奉联合杏丁(银杏叶提取物)治疗大面积脑梗死的临床疗效。方法将经头颅CT或MRI证实的急性大面积脑梗死患者74例随机分为治疗组(33例)及对照组(41例)。治疗组给予依达拉奉30mg,每日两次;同时给予杏丁20mg,每日一次;对照组给予胞二磷胆碱0.75g,每日一次(所有药品均加入0.9%氯化钠注射液250ml中静脉注射,两组疗程均为14d)。两组患者早期均应用甘露醇脱水,水肿高峰期过后给予血液稀释治疗。根据神经功能缺损评分(NDS)和日常生活能力量表(ADL)来判定其疗效,并计算有效率。结果治疗组总有效率66.7%;对照组总有效率41.5%;两组差异有统计学意义(P<0.05)。治疗组未见有严重不良反应出现。结论依达拉奉联合杏丁治疗急性大面积脑梗死安全有效。

Objective To observe the clinical efficacy of Edaravone combined with Xingding （ Ginkgo biloba extract） on treating acute cerebral infarction of large area. Methods Total 74 patients with acute cerebral infarction of large area were randomly divided into two groups. One was the treatment group （n = 33 ） which was treated with Edaravone Injection 15mg in sodium chloride injection 250mL, iv, gtt, bid, accompanied by Xingding Injection 20mg in sodium chloride injection 250mL, iv, gtt, qd. The other was the control group （n = 41 ） which was treated with Citicoline Injection 0. 75g in sodium chloride injection 250mL, iv, gtt, qd. All patients were administrated Mannitol Injection and hemodilution, and all of them received the examination of CT or MRI before and after the treatment. The clinical effects were evaluated according to neurologic deficit score （NDS） and activity of daily living scale （ADL）. And effective rate was calculated after two weeks. Results The recovery degree of nervous function in treatment group was much better than that of control group （ P 〈 0. 05 ）. Effective rates were 66.7% and 41.5% in the treatment group and the control group respectively with a significant difference between the two groups （P 〈 0. 05 ）i No severe side - effect was detected in the treatment group. Conclusion The therapy of Edaravone combined with Xingding is effective and safe in treating acute cerebral infarction of large area.