摘要
目的:观察肺癌患者超声雾化吸入5氟尿嘧啶(5FU)的药动学及肺、癌组织中药物浓度,对超声雾化吸入法与常规用药法进行比较。方法:采用HPLC测定患者血清中的5FU浓度和手术患者正常肺组织与癌组织中的浓度,对血清药时数据拟合后观察有关的药动学参数。结果:平均吸收半衰期0.10h,分布和消除半衰期分别为0.15h和0.34h,达峰时间0.23h,峰浓度2.32μg·ml-1。术前雾化吸入20min的患者,术中所取肺组织和癌肿组织中5FU浓度分别为0.37μg·g-1和0.44μg·g-1。结论:超声雾化吸入5FU的吸收速度大于口服给药,癌组织内药物浓度较高,提示该给药方法是合理可行的。
OBJECTIVE: To determine the concentrations of fluorouracilum in serum, lungs and tumour in patients was lung cancer after inhaling fluorouracilum by ultrasonic atomizer, and check the method against the conventional methods. METHODS: 10 patients with lung cancer served as targets of the experiment. A high performance liquid chromatography method with a 5 μm Kromasil C18 column 4.6 mm×200 mm and a mobile phase consisted of acetonitrilemthanol0.025 mol·L-1 K2HPO4 solution (10∶40∶50) was used. After fluorouracilum inhaled 250 mg: 10 ml, serum samples were collected at 2, 5, 10, 20, 30, 45, 60, 90, 120, 240 min and tissue samples obtained duing operation. The data obtained were fitted with PKBPN1 pharmacokinetic progarm on a computer. RESULTS: The results showed that the disposion of fluorouracilum was conformed to a twocompartment model with t1/2Ka=0.10 h, t1/2α=0.15 h, t1/2β=0.34 h, tmax=0.23 h and cmax=2.32 μg·ml-1. The concentration of tissue of lung and tumour was 0.37 μg·g-1 and 0.44 μg·g-1. CONCLUSIONS: The assimilate rate for fluorouracilum is fast and the harmful effects are less and light with the inhaling fluorouracilum by ultrasonic atomizer rather than old preparation.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
1998年第1期33-35,共3页
Chinese Pharmaceutical Journal
关键词
超声雾化吸入
肺癌
药物动力学
氟脲嘧啶
fluorouracilum, inhaling by ultrasonic atomizer, lung cancer, pharmacokinetic, HPLC