可比特雾化吸入对哮喘夜间症状的疗效观察

Curative Effect of Using Aerosol Inhalant Atrovent and Ventolin Together to Cure Acute Episode of Asthma at Night

目的:观察联合吸入抗胆碱能药物和β2受体激动剂对哮喘患者夜间急性发作的疗效。方法:将伴有夜间症状的哮喘患者113例随机分成联合给药组和对照组,当患者夜间出现急性发作时,对照组单纯给予二羟丙茶碱静脉注射,联合给药组在此基础上同时给予抗胆碱能药物和β2受体激动剂联合雾化吸入,记录夜间急性发作症状缓解的时间。结果:联合给药组喘息的快速缓解率为66.7%,对照组的为39.0%,快速缓解率两组之间的差异具有统计学意义。另外联合给药组喘息缓解率为84.9%,对照组的为68.3%,两组喘息缓解率的差异也具有统计学意义。结论:抗胆碱能药物和β2受体激动剂联合雾化吸入不但能明显缩短夜间症状急性发作缓解所需的时间,并且也可以增加疗效。

Object：To survey curative effect of using aerosol inhalant Atrovent and Ventolin together to cure acute episode of asthma at night. Methods,, One hundred and thirteen asthma patients with acute episode at night were conducted in two different groups： combination treatment group and control group at random. When patients were in acute episode at night, control group only used neothylline, while combination tre＇atment group usded simultaneously neothylline and aerosol inhalant Atrovent and Ventolin. Then recorded interval between treatment and relief of night symptoms. Results： The fast relief ratios of combination treatment group was 66. 7% , the control group＇s was 39. 0%. There are significant differences between the two groups. And relief Ratios of combination treatment group was 84.9 %, the control group＇s was 68.3 %. There are also significant differences between the two groups. Conclusion： Our data suggest that it could shorten the interval between treatment and relief of night symptoms by using aerosol inhalant Atrovent and Ventolin together,and it could increase curative effect.