IVIG治疗重症吉兰-巴雷综合征的临床观察

Chinical observation on IVIG treating serious Guillain-Barre Syndrome

目的观察免疫球蛋白对重症吉兰-巴雷综合征的治疗效果。方法对21例重症吉兰-巴雷综合征患者予以静脉注射免疫球蛋白(IVIG),观察治疗前后神经功能改善情况,检测治疗前后脑脊液免疫系列、补体系列。结果16例痊愈,3例好转,2例无效。患者脑脊液中免疫球蛋白、补体经治疗后明显下降。结论IVIG治疗重症吉兰-巴雷综合征是较为有效的方法,可能与抑制了机体免疫反应有关。

Objective To investigate the effect of IVIG treating patients with serious Guillain-Barre Syndrome. Methods Twenty-one patients of Guillain-Barre Syndrome were treated with IVIG. The change of neurological functions was observed before and after the treatment. The immunoglobulin and complement in CSF were measured before and after the therapy. Results Twelve cases of patients fully recovered , Seven patients were improved , and two patients died. Both immunoglobulin and complement in CSF greatly decreased. Conclusion IVIG is effective for patients with Guillain-Barre Syndrome probably by inhibiting immune response of organism.