前胡丙素对肾血管性高血压大鼠脑肾ATP酶活力的影响

Effects of Praeruptorin C on Na^+ 、K^+ ATPase Activity in Cell Membrane of Brain and Kidney of Renovascular Hypertensive Rats

用两肾一夹模型观察肾血管性高血压大鼠血压与脑、肾细胞膜ATP酶活力的变化及前胡丙素（PraeruptorinC，Pra－C）对上述变化的影响。两肾一夹术后16周大鼠血压由（14．7±1．3）升至（27．1±1．8）kPa，脑、肾细胞膜Na+、K+－ATP酶活力分别下降至（7．3±2．5）和（14．7±1．2）μmol／（mg·h），Ca（2+）－ATP酶活力分别下降至（15．8±2．8）和（16．1±2．3）μmol／（mg·h）。与高血压组相比，Pra－c[20mg／（kg·d）]灌胃9周组在血压降至正常的同时，脑、肾细胞膜Na+、K+－ATP酶活力分别增高至（11．2±1．8）和（21．7±6．2）μmol／（mg·h），Ca+－ATP酶活力分别增高至（19．9±3．2）和（21．9±2．7）μmol／（Mg·h）。提示：肾血管性高血压时伴有脑、肾细胞膜ATP酶活力的下降，Pra－C的有效降压作用与维护脑、肾细胞膜ATP酶活力的正常有关。

Effects of praeruptorin C (pra-C) on systolic blood pressure (SBP) and ATPase activities in cell membrane of brain and kidney of two-kidney, one clip(2K1C) renovascular hypertensive rats (RHR) were studied 16 wk after 2K1C operation, SBP was elevated significantly from (14. 7±1. 3) to (27. 1± 1. 8) kPa; the Na+,K+-ATPasc activity (μmol mg(-1). hr(-1) ) of brain and kidney were decreased to (7. 3±2. 5) and (14. 7±1. 2) respectively; the Ca(2+)-ATPase activity was reduced to (15. 8±2. 8) and (16. 1± 2. 3) respectively. In rats treated by Pra-C(20 mg. kg(-1). d(-1), ig, 9 wk), SBP was significantly reduced; Na+, K-ATPase activity of brain and kidney was increased to (11. 2± 1. 8 ) and (21. 7 ±6. 2 ) respectively; Ca(2+)-ATPase activity was enhanced to (19.9 ± 3. 2 )and (21. 9± 2. 7) respectively. These results suggested that in RHR, ATPase activity of brain and kidney were decreased. Pra-C preserves ATPase activity in cell membrane of brain and kidney, which may attribute to its effect as a hypotensor.