反式-2,5-二芳基四氢呋喃合成的新方法

A Novel Approach to Synthesize trans-2,5-Diaryltetrahydrofuran

以（±）4，10-二氧杂三环［5，2，1，02,6］-癸-8-烯-3-醇为原料，经过芳基化、氧化、芳基化、环化、热分解和加氢反应，得到PAF新的拮抗物反式-2，5-二芳基四氢呋喃，并合成了化合物8．

A novel approach to synthesize trans-2, 5-diaryltetrahydrofuran is described. The new antagonists of PAF are obtained by six step reactions of arylation, oxidation, arylation,cyclization, hot decomposition and hydrogenation starting from (±) 4, 10-dioxatricyclo [5, 2,1, 02,6]-dec-8-ene-3-ole is described. Three title compounds (8a-8c) are synthesized.