摘要
A modified [3+1] cyclization procedure for the synthesis of calix [4]arenes was developed by using diglycol dimethyl ether as the solvent in place of dioxane which was generally adopted in previous literature. By the modified procedure, the yield of 5-bromo-11, 23-di-tert-butyl-17-methyl-25, 26, 27, 28-tetrahydroxycalix[4]arene from cyclic condensation of 2, 6-bis(2’-hydroxy-5’-tert-butyl-benzyl)-4-cresol and 2, 6-bis (bromomethyl)-4-bromophenol in the presence of TiCl4 was improved from less than 20％ to 40％, and the reaction time was reduced from several days to ten hours.
A modified [3+1] cyclization procedure for the synthesis of calix [4]arenes was developed by using diglycol dimethyl ether as the solvent in place of dioxane which was generally adopted in previous literature. By the modified procedure, the yield of 5-bromo-11, 23-di-tert-butyl-17-methyl-25, 26, 27, 28-tetrahydroxycalix[4]arene from cyclic condensation of 2, 6-bis(2'-hydroxy-5'-tert-butyl-benzyl)-4-cresol and 2, 6-bis (bromomethyl)-4-bromophenol in the presence of TiCl4 was improved from less than 20％ to 40％, and the reaction time was reduced from several days to ten hours.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1998年第1期83-85,共3页
Chemical Journal of Chinese Universities
关键词
杯[4]芳烃
逐步合成法
关环反应
杯芳烃
Calix[4]arene, Stepwise synthesis, Cyclization, Diglycol dimethyl ether
