精神分裂症患者药物治疗过程中血糖三酰甘油和甲状腺素水平分析

Analysis on the levels of blood glucose,triglyceride and serum thyroid hormone in patients with schizophrenia

目的比较精神分裂症患者服用抗精神病药物后血葡萄糖(glucose,GLU)、甘油三酰(triglyceride,TG)和游离三碘甲状腺原氨酸(fee-triio-dothyronine,FT3)、游离甲状腺素(free-thyroxine, FT4)、促甲状腺素(thyroidstimulathing hormone,TSH)水平的变化。方法观察不同抗精神病药物治疗的患者88例,分别于第2、4、8、12周检测血GLU、TG和甲状腺素水平。结果在治疗过程中,两组患者血GLU水平略有升高,但差异无统计学意义(P>0.05)。治疗4周后,TG水平都显著升高,氯氮平组差异有统计学意义(P<0.01),利培酮组差异也有统计学意义(P<0.05)。在治疗8周后,氯氮平组TG水平进一步升高(P<0.001),利培酮组TG水平也明显升高(P<0.01),此时两组FT_4水平都显著降低(P<0.05),而TSH水平却显著升高(P<0.05),且患者TG与FT_3、FT_4水平呈显著负相关。结论长期服用氯氮平和利培酮治疗的精神分裂症患者存在脂代谢紊乱,而这种紊乱与甲状腺素水平有显著的相关性。

Objective To confer the leves of blood glucose（GLU） and triglyceride （TG） and serum thyroid hormone in patients with schizophrenia in the cause of treatment. Methods To survey 88 patients with schizophrenia,and assess sera concentration of GLU and TG and thyroid hormone before treatment and during week 2,week 4,week 8,week 12. Results In the cause of treatments, the levels of GLU were up regulated slightly（P〉0.05）. The levels of TG rose obviously in the elozapine group （P〈0.01） and the risperidone group （P〈0.05）. Afer the treatment of week 8,the levels of TG were up regulated in the elozapine group（P〈0.01） and the risperidone group （P〈0.01） ,the level of freethyroxine（ FT4 ） were down-regulated （P 〈 0. 05 ）, while the level of thyroid stimulathing hormone （TSH） were up-regulated（P〈0.05）. As well as,there were a correlation between the levels of TG and free triioothyronine（FT3）, （FT4）. Conclusion The glycometabolism and lipid metabolism were disturbance in patients with schizophrenia treated with clozapine or risperidone,which were related to the of serum thyroid hormone.