摘要
目的:探讨阿托伐他汀对高脂血症患者的血脂调节及脂蛋白脂酶(LDL)作用。方法:选混合型高脂血症患者200例,口服阿托伐他汀6个月,分别于服药前、服药后1个月,服药后3个月、服药后6个月检测ALT、TG、TC、HDL-C、LDL-C、CK、CRP、LPL。结果:入选病例经治疗1、3、6个月,血脂指标TG、TC、LDL-C明显下降;C反应蛋白显著降低,与服药前相比均有显著性差异。阿托伐他汀连续服用6个月,对LPL水平没有影响。结论:阿托伐他汀有明显的降低血脂作用,但其机制与升高LPL无关。
Objective: To research the effect of atorvastatin on blood fat and lipoprotein lipase in hyperlipemia patients. Methods: 200 patients with hyperlipemia were selected in our research. They were all oral administrated with atorvastatin for 6 months. ALT, TG, TC, HDL-C, LDL-C, CK, CRP and LPL were determined before and after 1, 3, and 6 months of their administration. Resuits : After oral administrated with atorvastatin for 1, 3, and 6 months, index of blood fat were improved obviously. That is, TG, TC and LDL-C were all decreased significantly. CRP was also decreased that contrasted with before administration. But when LPL was concerned, it didn' t change after administration. Conclusion: Atorvastatin was very effective in decreasing blood fat, but the mechanism was not related to LPL.
出处
《药学与临床研究》
2008年第6期487-489,共3页
Pharmaceutical and Clinical Research