糖尿病肾病微型癥瘕病理假说及临床意义

Pathological Analysis of Diabetic Nephropathy with Micro-abdominal Mass

吕仁和教授在整理古代文献的基础上,结合临床实际,提出糖尿病肾病"微型癥瘕"病理假说,认为糖尿病肾病的发生、发展,实质上是消渴病久病不愈,热伤气阴,痰、郁、热、瘀互相胶结,积聚于肾之络脉,形成微型癥瘕,由瘕聚渐成癥积的过程。临证时应抓住微型癥瘕这一共性病理环节,在辨证施治的基础上。强调活血化瘀、软坚散结治法,以阻止其络脉微型癥瘕形成。

Based on the ancient traditional Chinese medical literature and with reference to modern medical research and clinical practice,we put forward a theory of micro-abdominal mass for analyzing the pathogenesis of diabetic nephtopathy(DN).It is suggested that the pathogenesis of DN is associated with the formation of micro-abdominal mass accumulated in kidney collaterals from Qi-yin consumption and the coagulation of phlegm,stagnation,heat and blood-stasis during the mistreatment of diabetic mellitus.Deficiency of healthy Qi is the cause and phlegm-heat stag- nating with blood-stasis is the pathological key of micro-abdominal mass accumulating in kidney collaterals of DN patients.In clinic,micro-abdominal mass should be taken into mind when ana- lyzing the pathogenesis of DN,and activating blood and removing blood-stasis,softening hardness to dissipate mass should be taken into consideration firstly during making treatment based on syn- drome differentiation.