原发性中枢神经系统淋巴瘤临床分析(附9例报告)

CLINICAL ANALYSIS OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA——REPORT OF 9 CASES

目的原发性中枢神经系统淋巴瘤（ＰＣＮＳＬ）较少见，但恶性高，现以９例作一临床分析。方法用病理和免疫组织化学检查证实９例ＰＣＮＳＬ，分析其诊断、治疗及预后。结果肿瘤位于大脑深部，呈浸润性生长，ＣＴ具有一定的特性，边界一般较清楚，呈略高密度，注射造影剂后增强明显。单纯的手术切除肿瘤无助于延长患者的生存期，多数病例预后恶劣。放疗和化疗有一定疗效。结论ＰＣＮＳＬ恶性高，发展快，早期诊断及治疗是延长患者生存期的关键。对脑内深部占位性病变应想到ＰＣＮＳＬ的可能。

Objective:Primary central nervous system lymphoma (PCNSL) is rather rare but highly malignant.A clinical analysis of 9 cases was reported.Methods:All cases were confirmed by pathological and immunohistochemical studies.Results:The lesions usually involved the deepseated structures,showed slight hyperdensity in plain CT, and could be enhanced homogeneously following contrast infusion.Because surgical removal of PCNSL provided little benefits for the survival time,CTguided needle biopsy followed by chemotherapy and/or radiotherapy might be an alternative therapeutic measure.Conclusions:PCNSL is highly malignant.When a space occupied lesion occurred in deepseated brain tissue,we should beware of PCNSL.