阿霉素毫微粒经动脉给药对大鼠肝肿瘤的疗效

THERAPEUTIC EFFECTS OF NANOPARTICLEENCAPSULATED ADRIAMYCIN ADMINISTERED VIA HEPATIC ARTERY AGAINST RATBEARING HEPATOMA

目的观察阿霉素毫微粒（ＮＡＤＭ）经动脉给药对大鼠肝肿瘤的疗效。方法以界面聚合法制备ＮＡＤＭ，建立大鼠移植性Ｗ２５６肝癌模型并随机分为四组，经肝动脉分别注入生理盐水、游离阿霉素（ＡＤＭ，２ｍｇ／ｋｇ）、游离阿霉素加空白毫微粒（ＡＤＭ＋ＮＰ，２ｍｇ／ｋｇ）与ＮＡＤＭ（２ｍｇ／ｋｇ）。结果经ＮＡＤＭ治疗的大鼠生存期显著延长（Ｐ＜０．０１），与ＡＤＭ及ＡＤＭ＋ＮＰ组相比对肿瘤生长的抑制更为明显（Ｐ＜０．０１），肿瘤坏死更广泛，更彻底。结论ＮＡＤＭ经动脉给药疗效肯定。

Objective:To observe the therapeutic effects against hepatoma with nanoparticleencapsulated adriamycin (NADM) administered via hepatic artery.Methods:NADM was prepared by the interfacial polymerization method. Normal saline,free adriamycin (ADM,2mg/kg),adriamycin plus blank nanoparticle (ADM+NP,2mg/kg),and NADM (2mg/kg) were injected respectively via the hepatic artery into four groups of rats bearing W256 liver carcinoma.Results:The survival time was prolonged in animals treated with NADM significantly (P<001);the tumor growth inhibition was more significant (P<001) and necrosis more extensive in comparison with animals received ADM and ADM+NP.Conclusions:Hepatic arterial infusion of NADM was more effective than ADM or ADM+NP.