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甲基重氮烷阳离子(CH3N2^＋)与DNA碱基的甲基化反应 被引量：1

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摘要 在B3LYP/6-31G**和MP2/6-311G**水平上,计算了终致癌物甲基重氮烷阳离子(CH3N2+)在气相和水溶剂中与四种DNA碱基上10个亲核位发生甲基化过程的反应机理.结果表明:在气相和溶剂中,终致癌物CH3N2+对碱基上相应亲核位的甲基化反应过程,活化能都比较小(<33.5kJ/mol),是容易进行的放热反应.所以,二甲基亚硝胺一旦形成终致癌物,则很容易与碱基形成癌变物.
作者 李澜 瞿志豪 王竑 李宗和
机构地区 上海应用技术学院 北京师范大学化学学院
出处 《中国科学（B辑）》 CSCD 北大核心 2008年第12期1075-1080,共6页 Science in China(Series B)
基金 上海市教育委员会(批准号:yyy-07015)资助项目
关键词 CH3N2^+ 碱基 甲基化
分类号 O621 [理学—有机化学]
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参考文献28

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同被引文献11

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中国科学（B辑）
2008年 第12期

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