双丙戊酸钠、氟桂利嗪单用与合用预防偏头痛的疗效观察

Effects of flunarizine and divalproex administered alone and in combination in the prophylaxis of migraine

目的:观察氟桂利嗪、双丙戊酸钠及氟桂利嗪合用双丙戊酸钠对偏头痛发作的预防作用。方法:将124例偏头痛患者随机分为氟桂利嗪组(41例,A组)、双丙戊酸钠组(42例,B组)及氟桂利嗪合用双丙戊酸钠组(41例,C组),治疗2个月后对上述3组预防效果进行比较。结果:A组与B组总有效率分别为70.73%及73.81%,预防疗效差异无显著性(P<0.05),C组有效率92.68%,较A组、B组疗效好。结论:氟桂利嗪、双丙戊酸钠及氟桂利嗪合用双丙戊酸钠对偏头痛发作均有较好的预防作用,氟桂利嗪合用双丙戊酸钠较单独应用其中一种有更好的预防效果,但可能带来更多的不良反应。

OBJECTIVE To compare effects of flunarizine and divalproex administered alone and in combination in the proph ylaxis of migraine. METHODS 124 patients with migraine were distributed randomly into flunarizine group（n = 41, A group） , divalproex group（n = 42, B group） and flunarizine-divalproex group（n = 41 ,C group）. After treatment of two months, the effective rates were compared among three groups. RESULTS The total effective rate was 70. 73% in A group and 73. 81% in B group, there was no significant difference between the two groups（P〈0. 05）. The total effective rate in C group （92. 68%） were significant higher than that in groups A and B. CONCLUSION These results indicate that both flunarizine and divalproex are effective in migraine prophylaxis. Combination of two drugs have better effects than single drug but may cause more side effects.