2-甲基吡啶的合成工艺

Synthesis Technology of 2-Methylpyridine

探讨了以乙炔和乙腈为原料制备高纯度2-甲基吡啶的合成工艺,通过实验确定了适宜的反应条件.结果表明,乙炔压力为1.1MPa、乙炔耗用量为7.332 g、反应温度为180℃、有机钴类催化剂用量为200mg、反应时间为12 h时,2-甲基吡啶收率可达50.88%.反应生成的混合溶液经过滤、间歇精馏制得含量大于98%的2-甲基吡啶产品.该工艺操作简单,收率较高,具有潜在的工业应用价值.

This paper proposes a novel synthesis technology of 2-methylpyridine from acetylene and acetonitrile, and determines the optimal synthesis conditions by experiments. The results indicate that 2-methylpyridine with a yield of 50.88% can be prepared in the optimal conditions, that is, an acetylene pressure of 1.1 MPa, an acetylene dosage of 7.332g, a reaction temperature of 180℃, an organic cobalt catalyst dosage of 200mg and a reaction period of 12 h, that 2-methylpyridine with a purity of more than 98% can be obtained ＇after the filtration and batch distillation of the reacted solution mixture, and that the proposed technology is potentially applicable in industry due to its simple operation and high yield.