摘要
在不同配比的乙醇/水溶液中,应用1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐/N-羟基硫代琥珀酰亚胺(EDC/NHS)体系交联了明胶纳米纤维膜。分析了交联后明胶纳米纤维膜的宏观形貌、微观结构、吸水率、质量损失率、力学性能,并对交联后明胶纳米纤维膜的体外降解过程进行了实验研究。结果表明,在无水乙醇溶液中交联的明胶纳米纤维膜综合性能良好;交联后的明胶纳米纤维膜40d完全降解,降解过程中吸水率和pH值变化不大,有利于在生物医用材料方面的广泛应用。
Gelatin nanofiber mats have been crosslinked with the same concentration of 1-ethyl-3-（3-dimethylaminopropyl） carbodiimide/N-hydroxysuccinimide （EDC/NHS） in mixtures of alcohol/water with different composition. According to the analysis of their macroscopic performance, microscopic structure, swelling, dissolution and mechanical properties, gelatin nanofiber mats which were crosslinked in absolute alcohOl showed the best overall performance. In an vitro degradation process, it was found that the gelatin nanofiber membrane could completely degrade in 40 days. The material obtained by such crosslinking may have widespread application in the biological medical material domain.
出处
《北京化工大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2008年第6期58-62,共5页
Journal of Beijing University of Chemical Technology(Natural Science Edition)
基金
国家自然科学基金(30471907)
关键词
明胶
电纺丝
交联
体外降解
gelatin
electrospinning
crosslinking
in vitro degradation
