血液病合并肺结核T淋巴细胞亚群的表达

Expression of T-lymphocyte subsets in Hematological Diseases complicated with Pulmonary Tuberculosis

目的了解血液病合并肺结核患者的免疫功能状态。方法分析住院的29例血液病合并肺结核患者的外周血T淋巴细胞亚群的表达,并与同期住院的单纯肺结核40例和单纯血液病30例相比较。结果血液病合并肺结核组与单纯血液病组、单纯肺结核组比较,CD3+无显著性差异(P均>0.05),而CD4+、CD4+/CD8+显著降低,CD8+显著增高(P<0.05或0.01)。结论血液病合并肺结核患者免疫功能低于单纯血液病和单纯肺结核患者。如何提高血液病合并肺结核患者机体细胞免疫功能,达到良好的疗效是临床医师值得注意的问题。

Objective To investigate the state of the immune functions in patients with hematological disease combined pulmonary tuberculosis. Methods The expression of T-lymphocyte subsets in 29 patients with hematological disease combined pulmonary tuberculosis hospitalized from May 2005 to May 2007 were tested . The results were compared with those of 40 cases with pulmonary tuberculosis and 30 cases with hematological disease hospitalized in the same period. Results The percentages of CD3^＋ in peripheral blood was no statistical significance difference （ P〉 0.05） in the hematological disease complicated with pulmonary tuberculosis, hematological disease and pulmonary tuberculosis. But the percentages of CD4^＋ ,the ratio of CD4^＋/CD8^＋ of the hematological disease complicated with pulmonary tuberculosis patients were much lower than those of hematological diseases and pulmonary tuberculosis（ P 〈0.05）, the percentages of CD8^＋ in patients with hematological disease combined pulmonary tuberculosis was obviously higher than those in patients of hematological disease and pulmonary tuberculosis（ P 〈0.05）. Conclusion The immune functions in patients with hematological disease combined pulmonary tuberculosis was lower than those of hematological disease and pulmonary tuberculosis. It high time for cinician to find a way to improve immune function and satisfactory curative effect of patients with hematological diseases complicated with pulmonary tuberculosis.