慢性胃炎患者血浆一氧化氮和内皮素水平的变化及意义

Level changes of plasma nitric oxide endothelin and their meanings in the patients with chronic gastritis.

目的：探讨一氧化氮（ＮＯ）、内皮素（ＥＴ）与慢性胃炎的关系。方法：分别通过镉还原层析加显色法和放射免疫分析法对４１例慢性胃炎患者和１２例健康人血浆ＮＯ及ＥＴ水平进行了测定。结果：轻度浅表性胃炎组ＮＯ、ＥＴ水平与正常对照组无显著性差异，重度浅表性胃炎组与萎缩性胃炎组ＮＯ、ＥＴ水平均显著高于前两组，幽门螺杆菌（ＨＰ）相关胃炎组二者水平均显著高于非ＨＰ相关胃炎组及正常对照组，非ＨＰ相关胃炎组ＮＯ水平虽高于正常组但无显著性差异，而ＥＴ水平亦显著高于正常组。结论：ＮＯ和ＥＴ参与了慢性胃炎特别是ＨＰ相关性胃炎的病理生理机制。

Objective:In order to study the relationship of chronic gastritis with NO and ET.Methods:The contents of plasma NO and ET were respectively determined with Greiss method and RIA.Results:The contents of NO and ET in mild CSG groups were both close to normal controls.The contents of NO and ET in sever CSG groups and CAG groups were significantly higher than those in the two former groups (P<005 respectively).The contents of NO and ET in HP-associated CG groups were significantly higher than those in non-HP-associated groups (P<005 respectively).[WT5”HZ]Conclusions:NO and ET were involved in the pathogenesis of chronic gastritis especially HP-associated CG.