急性混合细胞白血病6例临床分析

Clinical Analysis on 6 Cases of Acute Mixed Lineage Leukemia

目的探讨急性混合细胞白血病(MAL)的临床特征、生物学特点、治疗及预后。方法回顾性分析新乡市第一人民医院近8年收治的6例MAL患者的临床表现、实验室特征、治疗及转归。结果MAL以髓系和淋巴系抗原共表达为主,本组中B系和髓系双表达3例,T系和髓系双表达1例,T系、B系和髓系均表达1例。化疗效果差,完全缓解率低,中位生存期短。结论MAL的诊断以免疫学检查为主,治疗困难,预后差,尚无较佳化疗方案。

[Objective] To investigate the clinical features, biological characteristics, therapy and prognosis of Acute Mixed Lineage Leukemia （AMLL）. [Methods]6 cases of AMLL diagnosed in the First Peoples Hospital of Xinxiang City in the past 8 years were analyzed retrospectively. The clinical features, laboratory findings, treatment and outcome of patients were explored.[Results] Majority of patients with AMLL co-expressed myeloid and lymphocyte antigens. Among 6 cases, 3 cases co-expressed B lymphoid and myeloid antigens, 1 case co-expressed T lymphoid and myeloid antigens, and 1 case expressed B lymphoid, T lymph-oid and myeloid antigens all together. Chemotherapy showed lesser effect, complete remission rate was low, and median survival was short. [Conclusion] The diagnosis of AMLL chiefly depended on immunological examination. The therapy of AMLL was difficult and the prognosis was poor. There was no a good chemotherapy forms yet.