复方丹参、脑蛋白水解物治疗HIE疗效观察

Clinical Observation of Compound Salviae Miltiorrhizae Combined with Cerebroprotein Hydrolysate on the Treatment of HIE

目的探讨复方丹参与脑蛋白水解物联合应用治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法将新乡市中心医院自2007年2—11月入院治疗的新生儿缺氧缺血性脑病85例随机分为2组,对照组43例采用常规3项支持疗法和对症治疗,治疗组42例在对照组治疗基础上加用复方丹参注射液与脑蛋白水解物注射液联合应用,观察其疗效。结果治疗组总有效率为95.23%,对照组为76.74%,2组比较,差异有统计学意义(P<0.05)。结论复方丹参注射液与脑蛋白水解物注射液联合应用治疗HIE疗效确切,值得推广。

[Objective] To observe the Clinical effect of compound salvia miltiorrhiza combined with cerebroprotein hydrolysate on the treatment of neonatal Hypoxic Ischemic Encephalopathy （HIE）. [Methods] 85 cases with HIE in the Xinxiang Central Hospital from February to November in 2007 were divided randomly into two groups. The patients in the control group （43 cases） were treated by 3 items of routine supporting treatment and appropriate treatment. The patients in the treatment group （42 cases） were treated by compound salvia miltiorrhiza injection combined with cerebroprotein hydrolysate injection on the basis of the control group treatment. The therapeutic effects were observed. [Results] The effective rate of the treatment gruup（95.23% ） was higher than that of the control group（76.74%） significantly （P〈0.05）. [Conclusion]The combined application of compound salvia mihiorrhiza injection and cerebroprotein hydrolysate injection is an effective therapeutic method for HIE, which is worth recommending for widespread use.