疏血通联用低分子肝素治疗不稳定性心绞痛临床观察

Clinical Observation of Shuxuetong and Low Molecular Weight Heparin in Treatment of Unstable Angina

目的观察疏血通与低分子肝素联合治疗不稳定性心绞痛(UAP)的疗效。方法将88例患者随机分为治疗组与对照组。对照组(阿斯匹林与低分子肝素组)44例;治疗组44例在常规治疗基础上加用疏血通注射液6ml加入生理盐水250ml中静脉滴注,1次/d,治疗2周;低分子肝素钙0.4ml皮下注射,2次/d,治疗1周。观察心电图,UAP发作次数、强度及血液流变学参数。结果治疗组比对照组UAP的显效率显著增加,心绞痛缓解、消失时间显著缩短(均P<0.01),2组差异有统计学意义。结论疏血通联用低分子肝素能很好地控制UAP的发作,且无明显不良反应。

[Objective] To observe the effect of Shuxuetong and low molecular weight heparin in treatment of unstable angina （UAP）. [Methods] A total of 88 patients were divided into treatment group and control group （aspirin and low molecular weight heparin group ）, with 44 patients for each group. Shuxuetong injection of 6 ml and normal saline of 250 ml, 1 time/day, treatment for 2 weeks, subcutaneous injection of low molecular weight heparin of 0.4 ml, 2 times / day, treatment for 1 week, were adminis-trated to treatment group with the conventional therapy. Electro-cardiogram, UAP attack frequency and intensity, and blood rheology parameters were observed. [ Results] UAP marked a significant increase in efficiency in the treatment group than the control group, time for angina emission and disappearance significantly shortened （P 〈 0.01 ）, with significant difference. [ Conclusion] Shuxue-tong and low molecular weight heparin can control UAP attack well, without obvious adverse reactions.