带脂肪皮肤移植的实验研究与临床应用

Experimental and clinical study of skin with fat graft

为提高带脂肪皮肤移植的成活率，进行了实验和临床研究。以小猪躯干部带脂肪皮肤移植为实验模型，计算经局部加温、降温，局部及全身使用抗缺氧剂（ＱＳＤ及ＱＨＤ）等处理后皮片的成活率。观察了临床应用带脂肪皮肤移植１５９例的治疗效果。结果表明经局部加温、局部及全身使用抗缺氧剂ＱＳＤ及ＱＨＤ后，皮片的成活率分别为９３．５％±５．８％、９１．５％±４．９％和８４．０％±４．３％，三者均明显高于未处理组。临床应用１５９例带脂肪皮肤移植的成活率达９９．２％，治疗效果满意。

Experimental and clinical studies were carried out to improve the graft taking rates of skin with fat graft on trunks of piglets.The graft taking rates were estimated after local heating, local cooling, and local and systematical uses of antihypoxic agents QSD and QHD.The therapeutic effect of skin with fat graft was clinically observed in 159 cases. The resulds shewed that local heating and local and systematical uses of QSD and QHD could improve the graft taking rates of porcine free skin graft with subcutaneous fat of 4 mm in thinkness.The skin graft taking rates in the groups of piglets treated by these three measures were 93.5% ± 5.8% , 91.5% ± 4.9.and 84.0% ±4.3% , respectively, significantly higher than that in the of untreated group (P<0.01) .The taking rate of clini- cal application to 159 cases was 99.2% with satisfactory therapeutic effect,