尖锐湿疣和假性湿疣的鉴别和激光治疗

Differential Diagnosis and Laser Treatment of Acuminate Condyloma and Pseudocondyloma in Females

尖锐湿疣和假性湿疣早期的临床表现和病理形态有些近似，易误诊，并涉及防治措施的不同。设想通过临床观察、实验室检查和特殊检测，包括滴虫、霉菌、淋菌、梅毒螺旋体、衣原体、支原体、癌涂片、病毒ＨｐＶ６，１１型（核酸斑点杂交法）、ＨｐＶ－Ａｇ（免疫组化ＡＢＣ法）和细胞ＤＮＡ图像分析法，预测有无恶变的趋势。设对照组，一一进行χ２检验，得出鉴别二者的要点。尖锐湿疣组１１２例、假性湿疣组２８２例、对照组１５９例。提出ＣＯ２激光治疗为有效的方法，并探讨了两病之间的关联和二者与癌前病变及性传播疾病的关系。

isdiagnosis between condyloma acuminate and pseudo-condyloma in their early stage may easily happen in clinical practice due to some similarity in their clinical manifestation and pathological appearance. The purpose of this study is to explore the differential diagnosis and effectiveness of laser treatment of those two types of diseases. 112 cases of condyloma acuminate, 282 cases of pseudocondyloma and 159 control cases with neither condyloma acuminate nor pseudocondyloma were studied by clinical observation and related laboratory tests including trichomoniasis, fungus, gonococcus, USR, mycoplasma huminis, chlamydia, pap smear, detection of HpV6,11 types by dotblot hybridization, detection of HpVAg by immunohistochemical ABC technique, and image cytometry by advanced CAS 200 DNA analyzer. Through the above mentioned examinations and statistical analysis (χ2 test), the major points of their differential diagnosis were established. Complete cure (100%) of both condyloma acuminate and pseudocondyloma was acheived by CO_2 laser therapy. The correlations between those diseases and precancerous lesions, and between pseudocondyloma and STD were discussed.