摘要
本文根据动物实验模型的设计，研究了中药丹参对丝裂霉素Ｃ（ＭＭＣ）诱发雄性小鼠过生殖细胞遗传损伤的防护效应。雄性昆明小鼠随机分成８组，每组１５只，实验组分别注射高、中、低剂量丹参和ＭＭＣ，观察动物的精子畸形率、早期精细胞微核率和精原细胞染色体畸变率。结果表明，中药本身无诱变损伤作用，而对ＭＭＣ有拮抗抑制作用。提出中药丹参具有抗ＭＭＣ诱发小鼠生殖细胞遗传损伤的作用。
In this paper,the relationship between the MMC inducing effect and protecting effect of Salvia mitiorrhiza,was studied in germ-cell of Kunming mice。Male mice divided randomly into eight groups with 15 mice each group。In experimental groups different dose of Salvia mitiorrhiza and same dose of MMC were administrated。The chromosome aberration(CA) of spermatogonia,sperm aberration and micronucleus(MN) of early spermatids were observed。The results showed that chinese medicine itself has no genetoxic effect,bus can significantly decrease CA,MN and sperm aberration frequencies induced by MMC (P<0.01). The results indicated that the chinese medicine Salvia mitiorrhiza may be an antimutagen。
出处
《癌变．畸变．突变》
CAS
CSCD
1998年第1期39-42,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
丹参
生殖细胞
精子畸形
微核
染色体畸变
Salvia miltiorrhiza
Germ-cell
Sperm aberration
Chromosome aberration
Micronucleus
