女性肺癌的遗传流行病学研究

Genetic Epidemiology Study on Lung Cancer in Women

通过对１７６个女性肺癌先证者核心家系和１９４个女性对照的核心家系资料分析。发现女性肺癌先证者的一级亲属（父母、同胞）患肺癌的危险性是对照一级亲属（父母、同胞）的１．６７倍，且差异具有显著性。其中女性亲属患肺癌的危险性显著高于对照的女性亲属，ＯＲ值为２．８１（Ｐ＜０．０１）。女性肺癌的遗传度为２０．５４％，遗传因素是女性肺癌的重要危险因素。女性肺癌先证者的女性亲属对肺癌的遗传易感性比男性亲属高。这些结果有助于全面阐明云南省宣威县女性肺癌高发的原因。

194 cases unclear families as a control were compared with 176 cases female lung cancer probands nuclear families.We found that the relatives (parents and siblings) of probands were 1.67 times greater risk of lung cancer than the controls relatives(parents and siblings),and the difference was statistically significant.The OR of lung cancer among female relatives was 2.81(P<001).The heritability of lung cancer was 20.54% in the women.Those results were helpful to explain the highest incidence among women in Xuan Wei County.