血清前清蛋白水平与脓毒症的早期诊断

Study on the relationship between serum level of prealbumin and the early diagnosis of sepsis

目的探讨血清前清蛋白(PA)在鉴别诊断全身性炎性反应综合征(SIRS)与脓毒症(sepsis)中的价值,研究血清PA能否对脓毒症的早期诊断提供帮助。方法共有48例SIRS患者及36例sepsis患者入选。在患者入选后的第2天进行PA测定,并进行急性生理和慢性健康状况评分。结果sepsis组PA水平明显低于SIRS组,差异有统计学意义(P<0.01),若以PA<170mg/L作为诊断sepsis的阳性标准,PA的敏感性和特异性分别为80.55%和87.50%。结论血清PA有助于早期诊断sepsis。

Objective To investigate the clinical significance of serum prealbumin （PA）in the differential diagnosis of SIRS and sepsis, to explore the serviceability of serum prealbumin to diagnose early sepsis. Methods Fourty eight patients with SIRS （SIRS group） and 36 patients with sepsis （sepsis group） were enrolled in the study. The serum level of prealbumin was measured for all cases on 2nd day of studying. Meanwhile,APACHEⅡ score was evaluated. Results The serum level of preaibumin in sepsis group was significantly lower than that in SIRS group （P〈0.01）. When PA〈170 mg/L was taken as the diagnostic standard of sepsis,the testis sensitivity and specificity was 80.55% and 87.50% respectively. Conclusion The measurement of serum prealbumin contributes to early diagnosis of sepsis.