组织多肽特异性抗原检测在肺癌中的诊断价值

The diagnostic value of tissue polypeptide specific antigen in lung cancer

目的探讨血清组织多肽特异性抗原(TPS)的检测对肺癌的临床诊断价值。方法用酶联免疫吸附试验法分别检测160例肺癌患者与151例健康体检者的血清TPS水平并进行比较分析。结果肺腺癌、肺鳞癌、小细胞肺癌及大细胞肺癌的阳性率分别为81.4%、78.4%、70.0%、72.5%,肺癌的总阳性率为75.6%,健康对照组的阳性率为7.1%。肺癌的总阳性率与各病理类型肺癌的阳性率都明显高于健康对照组,差异有统计学意义(P<0.01)。结论肺癌患者血清TPS阳性检出率较高,对肺癌患者的临床诊断有应用价值,是诊断肺癌的一种敏感的肿瘤标志物。

Objective To investigate the diagnostic value of serum level of tissue polypeptide specific antigen （TPS） in patients with lung cancer. Methods The levels and positive rates of TPS in serum were determined by enzyme- linked immunosorbent assay in 160 patients and 150 normal controls. The detectve results were compared and analyzed. Results The positive rates of TPS in groups of lung adenocarcinoma,lung squamous carcinoma （SqCa）, small cell lung cancer （SCLC）,and megacell lung caner were 81.4 %, 78.4 %, 70.0 %, and 72.5% respectively; the total positive rate of lung caner group was 75.6 %. The positive rate of each of above groups was significantly higher than that of healthy control group （7.1%） （P〈0.01）. Conclusion The positive detection rate of TPS in serum is higher in patients with lung cancer,and TPS can be used as a useful and sensitive tumor marker in clinical diagnosis of lung cancer.