黑桑椹对老年大鼠的活血降脂作用研究

Study on activating blood and hypolipidemic effects of black mulberry on aged rats

目的:研究黑桑椹对老年大鼠的活血降脂作用。方法:老年大鼠被随机分为对照组、10%果汁组、10%桑椹果组3组,8周后,大鼠的血清和血液用于各项指标的。结果:与对照组相比,黑桑椹果汁和桑椹果组大鼠的红细胞超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、膜结合酶(Na+-K+-ATP酶)活性,以及高密度脂蛋白含量均增加;膜脂流动性得到改善;同时,桑椹组的血清和红细胞膜中脂质过氧化产物丙二醛(MDA)含量和血液总胆固醇含量降低;处理组抗动脉硬化指数与对照组相比显著升高(P<0.05)。结论:黑桑椹果与果汁具有一定的活血、降脂和抗动脉粥样硬化的效果。

Objective： To study the activating blood and hypolipidemic effects of black mulberry on aged rats. Methods： Aged rats were randomly divided into 3 groups. Treatment rats were fed with black mulberry fruits or juice, respectively. The blood of rats in treatment groups and control group was determined after 8 weeks treatment. Results： Compared to the control group, SOD, GSH-Px, the primary enzyme of the membrane Na^＋-K^＋-ATPase activities of rat erythrocytes and HDL-C in the blood treated by mulberry juice and fruits were increased, and the erythrocyte membrane fluidity of aged rats were improved; at same time, mulberry treatment significantly decreased MDA content in the serum and erythrocytes total cholesterol（TC） of rats. The anti-atherogenic indexes （AAI） were distinguished increased in the mulberry groups（P〈0.05）. Conclusion： Black mulberry fruits and juice have effects on activating blood, hypolipidemic and anti-atherosolerosis effects.