骨伤洗药二号对膝关节骨性关节炎的治疗作用和部分机制研究

A clinical study on the effect of prescription of GUSHANG Ⅱ in Treatment of Knee Osteoarthritis

目的观察中药骨伤二号熏洗法治疗膝关节骨性关节炎的临床疗效和对血清IL-1、IL-6、TNF-α的影响。方法膝关节骨性关节炎60例,分成治疗组和对照组。分别采用中药熏洗方法和关节腔内注射透明质酸钠治疗,观察两组患者的临床症状、体征以及血清IL-1、IL-6、TNF-α变化。结果骨伤二号洗药在总疗效、消除疼痛、改善关节功能、日常生活能力、最大步行距离及消除关节肿胀等方面均存在明显优势,对于降低血清中IL-1、IL-6、TNF-α等炎性介质的含量方面则与对照组差异不大。结论中药骨伤二号熏洗方法和关节内注射透明质酸钠的方法均能治疗膝关节骨性关节炎,且中药熏洗方法的方法显示了比注射透明质酸钠更大的优势。

Objective To observe the effect of prescription of GUSHANG Ⅱ in treatment of knee Osteoarthritis. Methods 60 cases of OA of knee were divided into the experimental arm treated by GUSHANG Ⅱ and the control arm treated by sodium hyaluronate（SH）. In both arms, the level changes in serum of IL-1, IL- 6, and TNF-α were measured by ELISA before and after therapy. In statistical analysis between 2 factors and lineal relative recurrence were adopted. Results The result showed that there was a significantly difference in comparing the total effective rates of the two arms ; there was significant difference in relieving ache, improving dysfunction of joint,improving the capacity of dairy live and walking ; there was obviously significant difference in swelling of joint. There was no difference in the level changes in serum of IL-1, IL-6, and TNF-α after therapy. Conclusion It was suggested that GUSHANG Ⅱ and SH had significant effect to OA of knee, however GUSHANG Ⅱ is superior to SH in some aspects.