盐酸乙哌立松治疗伴有抑郁和（或）焦虑症状的紧张型头痛

Eperisone hydrochloride in treating tension type headache with depression and/or anxiety

目的 探讨治疗紧张型头痛伴有抑郁和（或）焦虑状态的有效方法。方法将伴有抑郁和（或）焦虑症状的紧张型头痛患者136例随机分为两组，即治疗组用盐酸乙哌立松加抗抑郁焦虑药，对照组仅用抗抑郁焦虑药，服药2周、4周后对头痛症状及抑郁、焦虑症状进行评估。结果治疗组明显减少头痛发作次数，缩短头痛发作持续时间，显著减轻头痛程度（第2周P〈0．05，第4周P〈0．01），同时能减少汉密尔顿抑郁量表（HAMD）（第2周、第4周P均〈0．01）及汉密尔顿焦虑量表（HAMA）评分（第2周P〈0．05，第4周P〈0．01）。结论盐酸乙哌立松对伴有抑郁和（或）焦虑症状的紧张型头痛疗效显著。

Objective To research effective methods of treating tension - type headache with de pression and/or anxiety. Methods One hundred and thirty - six tension - type headache cases with depression and/or anxiety were divided into two groups randomly, which included drug group treated with eperisone hydrochloride and anti - depression drug, and control group treated with anti - depression drug only. Assessed the curative effect after 2 weeks and 4 weeks treating. Results The frequency decreased, persistence time shortened and degree lessened in drug group of headache （2 weeks P 〈 0.05. 4 weeks P 〈 0. 01 ）. And eperisone hydrochloride also decreased HAMD （ 2 weeks and 4 weeks P 〈 0.01 ） and HAMA （ 2 weeks P 〈 0. 05. 4 weeks P 〈0. 01 ）. Conclusions The therapeutic effect of eperisone hydrochloride in tension - type headache with depression and/or anxiety is significant.