痰热清注射液与无创通气联合治疗病理产科并发急性肺损伤疗效观察

Non-invasive Mechanical Ventilation and Tanreqing Injection in Treating Acute Lung Injury with Pathologic Pregnancy

目的探讨痰热清注射液联合无创正压通气在治疗病理产科并发急性肺损伤(ALI)中的作用。方法将我院中心ICU收治病理产科并发ALI 35例患者随机分为两组,治疗组予痰热清注射液联合无创正压通气治疗,对照组予单一无创正压通气治疗;监测患者自觉症状、生命体征、血气分析、PaO2/FiO2及使用无创正压通气时间等指标。结果35例无创正压通气治疗,成功34例,占97.14%(34/35);治疗组6、12h患者呼吸频率、心率、PaO2、PaO2/FiO2改善较对照组明显,无创正压通气时间治疗组低于对照组。结论病理产科是ALI发生的高危人群。痰热清能减轻ALI的进一步加重,有效缩短无创正压通气的时间,有助提高患者机械通气耐受性,赢得抢救时机,阻断向ARDS进展。

Objective： To discuss the effect of non - invasive mechanical ventilation（NIPPV） and Tanreqing Injection on acute lung injury with pathologic pregnancy. Methods： 35 cases of acute lung injury in pathologic pregnancy were randomly divided into treatment group and control group. The treatment group was treated with NIPPV and Tanreqing Injection meanwhile control group was treated with NIPPV only. The rational symptom of patients, vital sign, blood gas analysis and PaO2/FiO2 were monitored. Results： 34 cases succeed in NIPPV and efficiency was 97. 14% （34/35） . The heart rate and PaO2, PaO2/FiO2 of treatment group improved more significantly than control group at 6, 12 h. The NIPPV time of treatment group was shorter than control group. Conclusion： Pathologic pregnancy is the high risk group to occur acute lung injury. Tanreqing Injection could relieve the ALI, shorten the NIPPV time, improve the tolerance to mechanical ventilation and prevent patients from ARDS.